CDP-Choline (Citicoline) in Bulk: What Formulators Should Know

CDP-choline — also known as citicoline — is one of the most requested ingredients in the cognitive-support supplement category. For manufacturers formulating nootropic blends, focus beverages, or standalone supplements, understanding what citicoline is, how branded and generic forms differ, and how to handle it in production is essential. This guide covers the practical points for sourcing CDP-choline in bulk.

What Is CDP-Choline (Citicoline)?

Citicoline (cytidine 5'-diphosphocholine, CAS 987-78-0) is a naturally occurring compound that serves as an intermediate in the synthesis of phosphatidylcholine, a major structural component of cell membranes. It is supplied as a white crystalline powder, soluble in water, and is used in supplement and functional product formulations as a source of both choline and cytidine.

Cognizin®: the Branded Form

Cognizin® is a branded, clinically studied form of citicoline manufactured by Kyowa Hakko. For formulators, the branded ingredient offers several advantages over generic citicoline:

• Traceability: a documented manufacturing process and consistent quality from a single producer.
• Clinical backing: the branded form has been used in published human studies, which supports marketing positioning (subject to applicable claim regulations).
• Label recognition: the Cognizin® name on a label signals ingredient quality to informed consumers in the nootropics category.

Typical Applications

• Nootropic supplements: capsules and tablets, often combined with L-theanine, caffeine, or B vitamins.
• Focus and gaming beverages: RTD drinks and powder sticks in the cognitive-performance segment.
• Functional powders: greens blends and all-in-one formulas with a cognitive component.

Formulation and Handling Notes

• Solubility: citicoline is water-soluble, making it suitable for beverages and drink mixes.
• Stability: store in a cool, dry place in sealed containers; the powder is hygroscopic and should be protected from moisture during handling.
• Taste: mildly sour-bitter at higher doses — flavour systems in beverages should account for this.

Regulatory Considerations in Canada

In Canada, cognitive-support ingredients are typically regulated under the Natural Health Products (NHP) framework, which requires a Natural Product Number (NPN) and compliant claims. Any marketing claim must be supported and aligned with the applicable monograph or evidence package. We recommend involving a regulatory consultant early in development.

Specifications at a Glance

• CAS number: 987-78-0
• Appearance: white crystalline powder
• Solubility: freely soluble in water

A full certificate of analysis (COA) is available on request for every lot.

Buying Bulk CDP-Choline in Canada

LiquidShop supplies Cognizin® (CDP-choline) in bulk by the kilogram for Canadian supplement and beverage manufacturers. Sourcing from a Canadian supplier means shorter lead times and simplified logistics for your production schedule. Certificates of analysis are available on request. Contact us to discuss your formulation and bulk pricing.